IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling
Abstract
Mitochondrial structure has a central role both in energy conversion and in the regulation of cell death. We have previously shown that IF1 protects cells from necrotic cell death and supports cristae structure by promoting the oligomerisation of the F1Fo-ATPsynthase. As IF1 is upregulated in a large proportion of human cancers, we have here explored its contribution to the progression of apoptosis and report that an increased expression of IF1,...
Paper Details
Title
IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling
Published Date
Jan 25, 2013
Journal
Volume
20
Issue
5
Pages
686 - 697
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Notes
History