Mst1 Is an Interacting Protein that Mediates PHLPPs' Induced Apoptosis
Abstract
PHLPP1 and PHLPP2 phosphatases exert their tumor-suppressing functions by dephosphorylation and inactivation of Akt in several breast cancer and glioblastoma cells. However, Akt, or other known targets of PHLPPs that include PKC and ERK, may not fully elucidate the physiological role of the multifunctional phosphatases, especially their powerful apoptosis induction function. Here, we show that PHLPPs induce apoptosis in cancer cells independent...
Paper Details
Title
Mst1 Is an Interacting Protein that Mediates PHLPPs' Induced Apoptosis
Published Date
May 1, 2010
Journal
Volume
38
Issue
4
Pages
512 - 523
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