Colorectal Cancer Stem Cells: From the Crypt to the Clinic
Abstract
Since their first discovery, investigations of colorectal cancer stem cells (CSCs) have revealed some unexpected properties, including a high degree of heterogeneity and plasticity. By exploiting a combination of genetic, epigenetic, and microenvironmental factors, colorectal CSCs metastasize, resist chemotherapy, and continually adapt to a changing microenvironment, representing a formidable challenge to cancer eradication. Here, we review the...
Paper Details
Title
Colorectal Cancer Stem Cells: From the Crypt to the Clinic
Published Date
Dec 1, 2014
Journal
Volume
15
Issue
6
Pages
692 - 705
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