Original paper
Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor
Abstract
A significant fraction of the β-amyloid precursor protein is proteolytically processed to yield large secreted forms (sAPP). These proteins have pleiotropic effects which potentially involve control of gene expression. We have investigated the influence of sAPP on the class of transcription factors which bind κB enhancer sequences. Transcription dependent on a κB element was enhanced by sAPP in several cell lines, as measured by expression of a...
Paper Details
Title
Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor
Published Date
Aug 1, 1996
Journal
Volume
40
Issue
1
Pages
116 - 126
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Notes
History