Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis
Abstract
Two-pore channels (TPC1, 2, and 3) are recently identified endolysosmal ion channels, but remain poorly characterized. In this study, we show for the first time a role for TPC1 in cytokinesis, the final step in cell division. HEK 293 T-REx cells inducibly overexpressing TPC1 demonstrated a lack of proliferation accompanied by multinucleation and an increase in G2/M cycling cells. Increased TPC1 was associated with a concomitant accumulation of...
Paper Details
Title
Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis
Published Date
Jan 2, 2015
Journal
Volume
9
Issue
1
Pages
21 - 29
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History