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#1Wei Shuai (WHU: Wuhan University)H-Index: 4
#2Bin Kong (WHU: Wuhan University)H-Index: 6
Last. He Huang (WHU: Wuhan University)H-Index: 43
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Myeloid differentiation protein 1 (MD1) is exerted an anti-arrhythmic effect in obese mice. Therefore, we sought to clarify whether MD1 can alter the electrophysiological remodeling of cardiac myoc...
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#1Marià AlemanyH-Index: 28
#2Luis Mifsud GrauH-Index: 1
Last. Sara León CariñenaH-Index: 1
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Congenital hyperinsulinemic hypoglycemia is the most frequent cause of persistent and recurrent hypoglycemia in the first years of life and in many patients rare genetic variants can be identified. Recently a case of congenital hyperinsulinemic hypoglycemia and a severe neurodevelopmental syndrome due to a mutation in the voltage-gated Cav1.3 Ca(2+) channel CACNA1D gene has been reported which required long-term treatment with diazoxide. This suggested CACNA1D variants as a potential cause for t...
1 CitationsSource
#1Jingyuan Li (PRC: China Medical University (PRC))
#2Siqi Wang (PRC: China Medical University (PRC))
Last. Liying Hao (PRC: China Medical University (PRC))H-Index: 14
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Residue Thr1604 in the CaV1.2 channel is a Ca(2+)/calmodulin dependent protein kinase II (CaMKII) phosphorylation site, and its phosphorylation status maintains the basic activity of the channel. However, the role of CaV1.2 phosphorylation at Thr1604 in myocardial hypertrophy is incompletely understood. Isoproterenol (ISO) was used to induce cardiomyocyte hypertrophy, and autocamtide-2-related inhibitory peptide (AIP) was added as a treatment. Rats in a myocardial hypertrophy development model w...
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#1Robin N. Stringer (Charles University in Prague)
#2Joanna LazniewskaH-Index: 13
Last. Norbert WeissH-Index: 19
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Cav3.2 T-type calcium channels play an essential role in the transmission of peripheral nociception in the dorsal root ganglia (DRG) and alteration of Cav3.2 expression is associated with the development of peripheral painful diabetic neuropathy (PDN). Several studies have previously documented the role of glycosylation in the expression and functioning of Cav3.2 and suggested that altered glycosylation of the channel may contribute to the aberrant expression of the channel in diabetic condition...
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#1Ye Han (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Kyle Lyman (Stanford University)H-Index: 2
Last. Dane M. Chetkovich (VUMC: Vanderbilt University Medical Center)H-Index: 2
view all 4 authors...
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed throughout the mammalian central nervous system (CNS). These channels have been implicated in a wide range of diseases, including Major Depressive Disorder and multiple subtypes of epilepsy. The diversity of functions that HCN channels perform is in part attributable to differences in their subcellular localization. To facilitate a broad range of subcellular distributions, HCN channels are bound by auxiliary subunit...
1 CitationsSource
#1Atousa Arbabian (University of Paris)H-Index: 6
#2Mircea Iftinca (Alberta Children's Hospital)H-Index: 2
Last. Sylvie Coscoy (University of Paris)H-Index: 3
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Transient receptor potential (TRP) channels form a family of polymodal cation channels gated by thermal, mechanical, or chemical stimuli, with many of them involved in the control of proliferation, apoptosis, or cell cycle. From an evolutionary point of view, TRP family is characterized by high conservation of duplicated genes originating from whole-genome duplication at the onset of vertebrates. The conservation of such "ohnolog" genes is theoretically linked to an increased probability of gene...
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#1Norbert WeissH-Index: 17
#1Norbert WeissH-Index: 13
Last. Norbert WeissH-Index: 19
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#1Michael Voldsgaard Clausen (AU: Aarhus University)H-Index: 5
Background and Purpose: Ion-channels are membrane proteins that can adopt several distinct structural conformations. Some of the conformations are open and allow the passage of ions through...
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#1Luyu Liu (RU: Rutgers University)H-Index: 2
#2Tibor Rohacs (RU: Rutgers University)H-Index: 34
The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires th...
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#1James Osei-Owusu (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
#2Junhua Yang (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 8
Last. Zhaozhu Qiu (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 15
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Severe local acidosis causes tissue damage and pain, and is associated with many diseases, including cerebral and cardiac ischemia, cancer, infection, and inflammation. However, the molecul...
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