Multimetallic Iridium‐Tin (Ir‐Sn₃) Catalyst in N‐Acyliminium Ion Chemistry: Synthesis of 3‐Substituted Isoindolinones via Intra‐ and Intermolecular Amidoalkylation Reaction

The multimetallic iridium‐tritin (Ir‐Sn 3 ) complex [Cp*Ir(SnCl 3 ) 2 {SnCl 2 (H 2 O) 2 }] ( 1 ) proved to be a highly effective catalyst towards COH bond activation of γ‐hydroxylactams, leading to a nucleophilic substitution reaction known as the α‐amidoalkylation reaction. Catalyst 1 can be easily synthesized from the reaction of (pentamethylcyclocyclopentadienyl)iridium dichloride dimer {[Cp*IrCl 2 ] 2 } and tin(II) dichloride (SnCl 2 ). In...