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Novel organotin complexes containing the 2,2′-bipyridine-3,3′,6,6′-tetracarboxylate. Helical supramolecular structure and cytostatic activity

Published on Feb 1, 2015in Journal of Organometallic Chemistry2.066
· DOI :10.1016/j.jorganchem.2014.11.027
Hanna Pruchnik11
Estimated H-index: 11
(Wroclaw University of Environmental and Life Sciences),
Tadeusz Lis31
Estimated H-index: 31
(UWr: University of Wrocław)
+ 2 AuthorsFlorian P. Pruchnik19
Estimated H-index: 19
(UWr: University of Wrocław)
Abstract
Reaction between 2,2′-bipyridine-3,3′,6,6′-tetracarboxylic acid (bptcH4) (1) and [Sn2Bu6O] in mild conditions proceeds with Sn-Bu bond cleavage giving polynuclear compounds. Complexes [(H2O)SnBu2(bptc)Sn2Bu6]·H2O (2), [(CH3OH)SnBu2(bptc)Sn2Bu6]·H2O (2a), [(DMF)SnBu2(bptc)Sn2Bu6] (2b) and [(DMF)SnBu2(bptc)Sn2Bu6]·0.5DMF·0.5H2O (3) were characterized using IR, NMR and ESI-MS spectroscopies. The X-ray structures of 1·H2O and (3) have been determined. Compound (3) is an exceptional polymer with seven-coordinate and five-coordinate Sn atoms. The Sn atoms are connected via screw-shaped C10H4N2(COO)4 bridges giving 3D helical network. The NMR and ESI-MS spectra reveal, that complexes in solutions dissociate giving mainly dinuclear complexes. Complex 2 interacts with adenosine 5′-monophosphate (AMP) via phosphate group. Compounds (2), (2a) and (2b) are very effective cytostatic agents against C-32, SNB-19, SH-4 and Colo-829 tumor cells.
  • References (30)
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References30
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#1Kandasamy Gopal (Central University of Rajasthan)H-Index: 15
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Last. Vadapalli Chandrasekhar (TIFR: Tata Institute of Fundamental Research)H-Index: 47
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The reaction of bis(tri-n-butyltin)oxide, [nBu3Sn]2O, with HO2C–C6H4–4-CF3 (RfTol-CO2H) affords a coordination polymer [nBu3SnO2C–RfTol]n (1). 1 undergoes hydrolysis in the presence of atmospheric moisture, at room temperature, resulting in the formation of the diorgano stannoxane [{nBu2SnO2C–RfTol}2O]2 (2). The transformation of 1 to 2 is accompanied by a Sn–C bond cleavage reaction. Formation of 2 also occurs in a direct reaction, involving [nBu3Sn]2O and RfTol–CO2H in the presence of water. 2...
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Background Metal-organic frameworks (MOFs) are made by linking inorganic and organic units by strong bonds (reticular synthesis). The flexibility with which the constituents’ geometry, size, and functionality can be varied has led to more than 20,000 different MOFs being reported and studied within the past decade. The organic units are ditopic or polytopic organic carboxylates (and other similar negatively charged molecules), which, when linked to metal-containing units, yield architecturally r...
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#2Małgorzata Latocha (Medical University of Silesia)H-Index: 11
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