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Hanna Pruchnik
Wroclaw University of Environmental and Life Sciences
48Publications
11H-index
312Citations
Publications 48
Newest
#1Marta Henklewska (Wroclaw University of Environmental and Life Sciences)H-Index: 2
#2Aleksandra Pawlak (Wroclaw University of Environmental and Life Sciences)H-Index: 6
Last.Bożena Obmińska-Mrukowicz (Wroclaw University of Environmental and Life Sciences)H-Index: 9
view all 6 authors...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Aleksandra Włoch (Wroclaw University of Environmental and Life Sciences)H-Index: 5
Last.Halina Kleszczyńska (Wroclaw University of Environmental and Life Sciences)H-Index: 15
view all 4 authors...
Interactions of tributyltin (TBTA) and triphenyltin (TPhTA) 2-[4 (dimethylamino)phenylazo]benzoates, showing promising cytostatic activity against tumor cells, with erythrocytes and with erythrocyte membranes and model lipid membranes have been investigated. The effect of TBTA and TPhTA on the erythrocyte and its model membrane was investigated by the microscopic and spectroscopic methods. Interaction of tin complexes with the membrane was determined on the basis of hemolytic activity, changes i...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Dorota Bonarska-Kujawa (Wroclaw University of Environmental and Life Sciences)H-Index: 10
Last.Halina Kleszczyńska (Wroclaw University of Environmental and Life Sciences)H-Index: 15
view all 5 authors...
The aim of the study was to determine changes incurred in lipid model membranes by polyphenol compounds from blueberry fruit of the genus Vaccinium that includes low, high and black blueberry. In particular, the effect of extracts on the packing order in the lipid hydrophilic phase, the fluidity of the hydrophobic phase, as well as the temperature of the phase transition in phospholipids was studied. Model membranes were formed of dipalmitoylphosphatidylcholine (DPPC) and egg phosphatidylcholine...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 33
view all 3 authors...
The aim of the study was to investigate and compare the interaction of tributyltin (TBTA) and triphenyltin (TPhTA) 2-[4 (dimethylamino)phenylazo]benzoates complexes with the lipid membrane and plasmid DNA. Both TBTA and TPhTA belong to the group of promising anticancer agents. Differential scanning calorimetry method was employed to examine the heat signal associated with phase transitions of liposomes formed from dipalmitoylphosphatidylcholine (DPPC) or DPPC/cholesterol and modified with TBTA a...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 33
view all 3 authors...
Structural properties of plasmid DNA and model lipid membrane treated with newly synthesized platinum(II) complex cis-[PtCl2{P(CH2CH2COOH)3}2] (cis-DTCEP for short) were studied and compared with effects of anticancer drug cisplatin, cis-[Pt(NH3)2Cl2] (cis-DDP for short). Time Correlated Single Photon Counting Fluorescence Correlation Spectroscopy (TCSPC-FCS) was employed to study interactions between those platinum complexes and DNA. The TCSPC-FCS results suggest that bonding of cis-DTCEP deriv...
#1Sylwia Cyboran-Mikołajczyk (Wroclaw University of Environmental and Life Sciences)H-Index: 2
#2Romuald Żyłka (Wroclaw University of Environmental and Life Sciences)H-Index: 5
Last.Halina Kleszczyńska (Wroclaw University of Environmental and Life Sciences)H-Index: 15
view all 7 authors...
Abstract Procyanidins, contained in many products abundant in human diet, exhibit high biological activity. However, this activity has not been fully explained at cellular and molecular levels. In this study, we determine the mechanism of interaction of procyanidin B3 with model lipid membrane. This mechanism was established on the basis of changes induced by B3 in the physical properties of lipid bilayer. The changes were investigated using steady state and time-resolved fluorescence, DSC, and ...
#1Marta Henklewska (Wroclaw University of Environmental and Life Sciences)H-Index: 2
#2Aleksandra Pawlak (Wroclaw University of Environmental and Life Sciences)H-Index: 6
Last.Bożena Obmińska-Mrukowicz (Wroclaw University of Environmental and Life Sciences)H-Index: 9
view all 4 authors...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
In the previous study, we showed that butyltin complexes with 2-sulfobenzoic acid (commonly referred to as BTsbz) exhibit a very wide biological activity. The BTsbz in vitro are very active cytotoxic agents against tumor cells—more effective than cisplatin and carboplatin (traditional anticancer drugs). These complexes are antibacterial agents against gram-positive and gram-negative bacteria, as well. The aim of the present study was to investigate the influence of BTsbz on the thermotropic phas...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Małgorzata Latocha (Medical University of Silesia)H-Index: 11
Last.Florian P. Pruchnik (UWr: University of Wrocław)H-Index: 19
view all 4 authors...
Abstract New pentamethylcyclopentadienyl complexes [M(C 5 Me 5 )Cl 2 (TCEP)] (M = Rh 1 , M = Ir 2 ) with P(C 2 H 4 COOH) 3 (TCEP) were investigated using IR, 1 H, 13 C, 31 P NMR and ESI-MS spectroscopies. Geometry optimization in the gas phase at the B3LYP/3-21G** level indicated that complex 1 has stable pseudooctahedral structure with large HOMO–LUMO gap. Calculated and experimental IR spectra of 1 agree very well. Cytostatic activity of compounds 1 and 2 was investigated against melanoma and ...
#1Aleksandra Włoch (Wroclaw University of Environmental and Life Sciences)H-Index: 5
#2Paulina Strugała (Wroclaw University of Environmental and Life Sciences)H-Index: 6
Last.Halina Kleszczyńska (Wroclaw University of Environmental and Life Sciences)H-Index: 15
view all 6 authors...
Buckwheat is a valuable source of many biologically active compounds and nutrients. It has properties that reduce blood cholesterol levels, and so reduces the risk of atherosclerosis, seals the capillaries, and lowers blood pressure. The aim of the study was to determine quantitative and qualitative characteristics of polyphenols contained in extracts from buckwheat husks and stalks, the biological activity of the extracts, and biophysical effects of their interaction with the erythrocyte membra...
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