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Degradation of the organotin polyether derived from dibutyltin dichloride and hydroxyl-capped poly(ethylene glycol) in trypsin and evaluation of trypsin activity employing light scattering photometry and gel electrophoresis

Published on Mar 1, 2013in Journal of the Chinese Advanced Materials Society
· DOI :10.1080/22243682.2013.771915
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Girish Barot11
Estimated H-index: 11
(BU: Boston University)
+ 2 AuthorsMichael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
Cite
Abstract
The degradation of water soluble organotin polyether in the presence of trypsin was studied. The polymer was found to be stable to 4 days, the typical cancer cell line testing time. This is consistent with polymer activity against cancer cell lines being a result of the non-degraded chain and not controlled release of the organotin moiety. As a control trypsin activity was studied employing light scattering photometry and gel electrophoresis. The trypsin was active degrading bovine serine albumin.
  • References (22)
  • Citations (12)
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References22
Newest
Published on Oct 1, 2012in Journal of Polymer Materials 0.41
Charles E. Carraher24
Estimated H-index: 24
,
Amit Gupta1
Estimated H-index: 1
,
Michael R. Roner19
Estimated H-index: 19
3 Citations
Published on Jul 1, 2011in Journal of Polymer Materials 0.41
Charles E. Carraher24
Estimated H-index: 24
,
Yoshinobu Naoshima12
Estimated H-index: 12
(Okayama University of Science)
+ 4 AuthorsAmitabh Battin6
Estimated H-index: 6
6 Citations
Published on May 27, 2011in Materials 2.97
Michael R. Roner19
Estimated H-index: 19
,
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
+ 1 AuthorsGirish Barot11
Estimated H-index: 11
(BU: Boston University)
Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very ...
17 Citations Source Cite
Published on Apr 15, 2011in Materials 2.97
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
+ 1 AuthorsGirish Barot11
Estimated H-index: 11
(BU: Boston University)
The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less ...
23 Citations Source Cite
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Frank D. Blum25
Estimated H-index: 25
(Missouri University of Science and Technology)
+ 8 AuthorsMichael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
Polymers in general and metal-containing polymers in particular are often sparingly soluble or insoluble, in contrast to small molecules. Thus, special significance is attached to characterization techniques that can be applied to the materials as solids. Here, three techniques are discussed that give structural information gained from the solid material. Mossbauer spectroscopy is a powerful technique that may give information on the structure about the metal-containing moiety for about 44 diffe...
11 Citations Source Cite
Published on Oct 21, 2009in Materials 2.97
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
Organotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of synth...
24 Citations Source Cite
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington),
Kimberly Shahi10
Estimated H-index: 10
(UTA: University of Texas at Arlington)
+ 2 AuthorsCharles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
Pancreatic cancer kills nearly all patients within 3–6 months after detection. There is no effective chemotherapy for it. We have found a number of organotin polymers that are effective at inhibiting pancreatic cancer cell lines with Chemotherapeutic Index values greater than two with some to values of 50.
24 Citations Source Cite
Girish Barot11
Estimated H-index: 11
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 3 AuthorsCharles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
A variety of dibutyltin polyethers have been synthesized employing the interfacial polymerization technique. The products are polymers with degrees of polymerization ranging from 60 to 390. Infrared spectral and mass spectral results are consistent with the proposed structure. The products show good inhibition of a variety of cancer cells including those associated with bone, breast, prostrate, and lung cancers. Some also show good viral inhibition of the HSV-1 (herpes simplex) and Vaccina (smal...
26 Citations Source Cite
Published on Apr 1, 2008in Journal of Polymer Materials 0.41
Anna Zhao3
Estimated H-index: 3
(UF: University of Florida),
Kimberly Shahi10
Estimated H-index: 10
(UTA: University of Texas at Arlington)
+ 6 AuthorsCharles E. Carraher24
Estimated H-index: 24
7 Citations
Cited By12
Newest
Published on Jun 26, 2018
Charles E. Carraher24
Estimated H-index: 24
,
Michael R. Roner19
Estimated H-index: 19
+ 1 AuthorsFrancesca Mosca2
Estimated H-index: 2
Group 4 metallocene polymers offer a wide variety of unique properties. Some of these are reviewed in this paper, including the ability to form fibers and to absorb laser radiation, thereby protecting materials containing them in small amounts; the possibility of becoming conductive materials through simple doping; increasing the productivity of damaged, old and mold-infested seeds through incorporation of plant growth hormones; and acting as anticancer drugs that inhibit a variety of human canc...
Source Cite
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 4 AuthorsFloyd Russell3
Estimated H-index: 3
(FAU: Florida Atlantic University)
ABSTRACTThe initial synthesis of DMSO and water-soluble hafnocene polyethers is described. The polyethers are formed through reaction of the hafnocene dichloride with various poly(ethylene glycols) employing commercially available reactants. Infrared, proton NMR, and MALDI MS results are consistent with the hafnocene-containing polyether structure. The materials are polymeric with chain lengths ranging from 1200 to 8 with moderate product yield. They exhibit good inhibition of a variety of cance...
1 Citations Source Cite
Published on Sep 1, 2017
Charles E. Carraher24
Estimated H-index: 24
,
Michael R. Roner19
Estimated H-index: 19
+ 7 AuthorsFloyd Russell3
Estimated H-index: 3
Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of ...
1 Citations Source Cite
Ayesha Kausar20
Estimated H-index: 20
(QAU: Quaid-i-Azam University)
ABSTRACTIn this work, blend membrane of polycarbonate (PC) and poly(styrene-co-allyl alcohol) (PSAA) was fabricated via phase inversion technique. Two types of nanofiller were employed for the membrane reinforcement including nano-zeolite (NZ) and bifiller of nano-zeolite-carbon nanotube (NZ-CNT). The PC/PSAA/NZ-CNT membrane with 10 wt.% filler revealed the formation of gyroid type microstructure. The tensile strength of PC/PSAA/NZ 1–10 was 42.1–55.5 MPa, whereas PC/PSAA/NZ-CNT 1–10 showed highe...
3 Citations Source Cite
Vaneet Kumar8
Estimated H-index: 8
,
N.C. Kothiyal12
Estimated H-index: 12
(NITJ: Dr. B. R. Ambedkar National Institute of Technology Jalandhar)
+ 2 AuthorsRenu Sharma1
Estimated H-index: 1
(NIMS University)
Polycyclic aromatic hydrocarbons (PAHs) are chemical compounds containing two or more fused benzene rings in linear, angular or cluster arrangement, consisting of only carbon and hydrogen. Polycyclic aromatic carbons (PACs) include the unsubstituted hydrocarbons (PAHs) and substituted PAHs (e.g. nitro-PAH, oxygenated PAH). PAHs are the most stable form of hydrocarbons having low hydrogen-to-carbon ratio and usually occur in complex mixtures rather than single compounds. They are usually generate...
5 Citations Source Cite
Published on Jul 2, 2016in Journal of Macromolecular Science, Part A 1.16
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 6 AuthorsLindsey Miller4
Estimated H-index: 4
(UTA: University of Texas at Arlington)
ABSTRACTWe describe the initial synthesis of DMSO and water-soluble titanocene polyethers through reaction of the titanocene dichloride and various poly(ethylene glycols) employing commercially available reactants. Infrared, proton NMR, and MALDI MS results are consistent with the titanocene-containing polyether structure. The materials are polymeric with chain lengths ranging from 1500 to 4. They exhibit good inhibition of a variety of cancer cell lines including two pancreatic cancer cell line...
4 Citations Source Cite
Published on Nov 22, 2015in International Journal of Polymeric Materials 2.26
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 7 AuthorsZamil Islam1
Estimated H-index: 1
(FAU: Florida Atlantic University)
The efforts described in this article are aimed at designing organotin polymers that control the growth of breast cancer and to identify structure/property relationships that assist in this goal. The growth of MCF-7 and MDA-MB-231 breast cancer cell lines is inhibited employing a wide range of organotin condensation polymers. The EC50 values are primarily dependent on the nature of the Lewis base but the CI50 is dependent on both the nature of the Lewis base and Lewis acid. A number of products ...
4 Citations Source Cite
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Alicia Morrison2
Estimated H-index: 2
(FAU: Florida Atlantic University)
+ 3 AuthorsLindsey Miller4
Estimated H-index: 4
(UTA: University of Texas at Arlington)
4 Citations Source Cite
Published on Aug 23, 2015in International Journal of Polymeric Materials 2.26
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 2 AuthorsAlisa Moric-Johnson4
Estimated H-index: 4
(UTA: University of Texas at Arlington)
Polyesters derived from the interfacial reaction of the salt of chelidonic acid and triphenylarsenic dibromide, triphenylantimony dichloride, and triphenylbismuth dichloride are formed in moderate yield using commercially available reactants. IR data shows new bands characteristic of the formation of the M-O bond. MALDI MS shows formation of ion fragment clusters to two units. The polymers were tested for their ability to inhibit prostate, colon, breast (two cell lines), and pancreatic (two cell...
6 Citations Source Cite
Pankaj Vikas2
Estimated H-index: 2
,
Vaneet Kumar8
Estimated H-index: 8
,
Saruchi8
Estimated H-index: 8
(NITJ: Dr. B. R. Ambedkar National Institute of Technology Jalandhar)
The objective of the present study was to ascertain contamination levels of soils with micro air pollutants (MAPs), toxic equivalency factor and statically analysis of carcinogenic MAPs, distribution behavior and human exposure during summer and winter round the year. The average MAP concentration were found to be 18.99 and 4.94, whereas concentration of 16 individual MAPs were found to vary between 0.03 and 199.23 μg/g and 0.009 and 29.4 μg/g, during summer and winter seasons, respectively. The...
1 Citations Source Cite