Degradation of the organotin polyether derived from dibutyltin dichloride and hydroxyl-capped poly(ethylene glycol) in trypsin and evaluation of trypsin activity employing light scattering photometry and gel electrophoresis

The degradation of water soluble organotin polyether in the presence of trypsin was studied. The polymer was found to be stable to 4 days, the typical cancer cell line testing time. This is consistent with polymer activity against cancer cell lines being a result of the non-degraded chain and not controlled release of the organotin moiety. As a control trypsin activity was studied employing light scattering photometry and gel electrophoresis....