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Girish Barot
Florida Atlantic University
29Publications
11H-index
299Citations
Publications 29
Newest
#1Charles E. Carraher (FAU: Florida Atlantic University)H-Index: 8
#2Michael R. Roner (UTA: University of Texas at Arlington)H-Index: 20
Last.Nandalall Sookdeo (FAU: Florida Atlantic University)H-Index: 3
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ABSTRACTA wide variety of organotin polyethers derived from the interfacial polymerization of dibutyltin dichloride and non-cancer inhibitory diols show decent to good inhibition of two human pancreatic cancer cell lines. In view of the general lack of ability of tested compounds to inhibit pancreatic cancer cell lines, this is significant. These cell lines are the AsPC-1 pancreatic cancer cell line which is an adenocarcinoma pancreatic cell line and the PANC-1 pancreatic cancer cell line which ...
4 CitationsSource
#1Charles E. Carraher (FAU: Florida Atlantic University)H-Index: 8
#2Michael R. Roner (UTA: University of Texas at Arlington)H-Index: 20
Last.Zamil Islam (FAU: Florida Atlantic University)H-Index: 1
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The efforts described in this article are aimed at designing organotin polymers that control the growth of breast cancer and to identify structure/property relationships that assist in this goal. The growth of MCF-7 and MDA-MB-231 breast cancer cell lines is inhibited employing a wide range of organotin condensation polymers. The EC50 values are primarily dependent on the nature of the Lewis base but the CI50 is dependent on both the nature of the Lewis base and Lewis acid. A number of products ...
5 CitationsSource
#1Charles E. Carraher (FAU: Florida Atlantic University)H-Index: 25
#2Michael R. Roner (UTA: University of Texas at Arlington)H-Index: 20
Last.Mohammed H. Al-huniti (FAU: Florida Atlantic University)H-Index: 4
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The current efforts described in this paper are aimed at developing compounds that inhibit the growth of prostate cancer and to identify structure/property relationships that will further assist us towards this goal. The growth of prostate cancer is affected employing a wide range of organotin condensation polymers. The EC50 values are primarily dependant on the nature of the Lewis base but the CI50 is dependent on both the nature of the Lewis base and Lewis acid. EC50 values down to the picogra...
11 CitationsSource
#1Charles E. Carraher (FAU: Florida Atlantic University)H-Index: 8
#2Michael R. Roner (UTA: University of Texas at Arlington)H-Index: 20
Last.Mohammed H. Al-huniti (FAU: Florida Atlantic University)H-Index: 4
view all 9 authors...
The efforts described in this paper are aimed at designing organotin polymers that control the growth of various cancers; here colorectal cancer and to identify structure/property relationships that will assist in this goal. The growth of colorectal cancer is affected employing a wide range of organotin condensation polymers. The EC50 values are primarily dependent on the nature of the Lewis base but the CI50 value is dependent on both the nature of the Lewis base and Lewis acid. EC50 values dow...
1 CitationsSource
#1Charles E. Carraher (FAU: Florida Atlantic University)H-Index: 25
#2Michael R. RonerH-Index: 20
Last.Theodore S. Sabir (FAU: Florida Atlantic University)H-Index: 1
view all 6 authors...
1 Citations
#1Charles E. Carraher (FAU: Florida Atlantic University)H-Index: 25
#2Michael R. RonerH-Index: 20
Last.Kimberly Shahi (UTA: University of Texas at Arlington)H-Index: 10
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1 Citations
#1Charles E. CarraherH-Index: 25
#2Michael R. RonerH-Index: 20
Last.Tiasha ArnoldH-Index: 1
view all 6 authors...
3 Citations
#1Charles E. Carraher (FAU: Florida Atlantic University)H-Index: 8
#2Girish Barot (FAU: Florida Atlantic University)H-Index: 11
Last.Michael R. Roner (UTA: University of Texas at Arlington)H-Index: 20
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The effect of solvent on the ability to inhibit a group of cell lines was studied employing a series of water-soluble dibutyltin polyethers derived from various hydroxyl-terminated poly(ethylene glycols). Molecular weight as a function of time was essentially unchanged for a period of 30 weeks for the polyethers. Variations in test media can affect biological activities on the cell level as well as at the molecular level. The current study involves the evaluation of the cellular effects when dim...
10 CitationsSource
#1Charles E. Carraher (FAU: Florida Atlantic University)H-Index: 8
#2Girish Barot (BU: Boston University)H-Index: 11
Last.Michael R. Roner (UTA: University of Texas at Arlington)H-Index: 20
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The degradation of water soluble organotin polyether in the presence of trypsin was studied. The polymer was found to be stable to 4 days, the typical cancer cell line testing time. This is consistent with polymer activity against cancer cell lines being a result of the non-degraded chain and not controlled release of the organotin moiety. As a control trypsin activity was studied employing light scattering photometry and gel electrophoresis. The trypsin was active degrading bovine serine albumi...
12 CitationsSource
#1Charles E. CarraherH-Index: 25
#2Theodore S. Sabir (APU: Azusa Pacific University)H-Index: 4
Last.Girish Barot (BU: Boston University)H-Index: 11
view all 4 authors...
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