Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies

Background: Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI). Objectives: We examined associations and compared effect sizes of these newly identified obesity susceptibility loci with various anthropometric traits and assessed their cumulative effects and predictive value for obesity risk. Design: We genotyped 12 single nucleotide polymorphisms (SNPs) from each...