Regulation of apoptosis at cell division by p34 ^cdc2 phosphorylation of survivin

The interface between apoptosis (programmed cell death) and the cell cycle is essential to preserve homeostasis and genomic integrity. Here, we show that survivin, an inhibitor of apoptosis over-expressed in cancer, physically associates with the cyclin-dependent kinase p34 cdc2 on the mitotic apparatus, and is phosphorylated on Thr 34 by p34 cdc2 -cyclin B1, in vitro and in vivo . Loss of phosphorylation on Thr 34 resulted in dissociation of a...