Original paper
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
Abstract
Achieving the full potential of zinc-finger nucleases (ZFNs) for genome engineering in human cells requires their efficient delivery to the relevant cell types. Here we exploited the infectivity of integrase-defective lentiviral vectors (IDLV) to express ZFNs and provide the template DNA for gene correction in different cell types. IDLV-mediated delivery supported high rates (13-39%) of editing at the IL-2 receptor common gamma-chain gene...
Paper Details
Title
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
Published Date
Oct 28, 2007
Journal
Volume
25
Issue
11
Pages
1298 - 1306
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Notes
History