Mrs2p Forms a High Conductance Mg2+ Selective Channel in Mitochondria
Abstract
Members of the CorA-Mrs2-Alr1 superfamily of Mg2+ transporters are ubiquitous among pro- and eukaryotes. The crystal structure of a bacterial CorA protein has recently been solved, but the mode of ion transport of this protein family remained obscure. Using single channel patch clamping we unequivocally show here that the mitochondrial Mrs2 protein forms a Mg2+-selective channel of high conductance (155 pS). It has an open probability of ∼60% in...
Paper Details
Title
Mrs2p Forms a High Conductance Mg2+ Selective Channel in Mitochondria
Published Date
Dec 1, 2007
Journal
Volume
93
Issue
11
Pages
3872 - 3883
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