Properties of the inner membrane anion channel in intact mitochondria
Volume: 24, Issue: 1, Pages: 77 - 90
Published: Feb 1, 1992
Abstract
The mitochondrial inner membrane possesses an anion channel (IMAC) which mediates the electrophoretic transport of a wide variety of anions and is believed to be an important component of the volume homeostatic mechanism. IMAC is regulated by matrix Mg2+ (IC50=38 µM at pH 7.4) and by matrix H+ (pIC50=7.7). Moreover, inhibition by Mg2+ is pH-dependent. IMAC is also reversibly inhibited by many cationic amphiphilic drugs, including propranolol,...
Paper Details
Title
Properties of the inner membrane anion channel in intact mitochondria
Published Date
Feb 1, 1992
Volume
24
Issue
1
Pages
77 - 90
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