Making new contacts: the mTOR network in metabolism and signalling crosstalk

Our understanding of the downstream effectors and upstream regulators of target of rapamycin (TOR) signalling continues to grow. In particular, recent global 'omics' studies have revealed physiological roles of mammalian TOR (mTOR) in protein, nucleotide and lipid synthesis, and other studies showed that Hippo, WNT and Notch signalling are novel regulators of mTOR. More than 20 years after its discovery, our understanding of target of rapamycin...