Nature Reviews Molecular Cell Biology
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Young and colleagues show that anti-cancer compounds can undergo partitioning into biomolecular condensates, affecting their activity.
#1Hugo Lavoie (UdeM: Université de Montréal)H-Index: 20
#2Jessica Gagnon (UdeM: Université de Montréal)H-Index: 2
Last. Marc Therrien (UdeM: Université de Montréal)H-Index: 22
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The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream components of a phosphorelay pathway that conveys growth and mitogenic signals largely channelled by the small RAS GTPases. By phosphorylating widely diverse substrates, ERK proteins govern a variety of evolutionarily conserved cellular processes in metazoans, the dysregulation of which contributes to the cause of distinct human diseases. The mechanisms underlying the regulation of ERK1 and ERK2, their mode o...
Human ageing is associated with high susceptibility to disease. Some aspects of ageing can be studied directly in humans and have revealed that ageing is influenced by many factors, including genetics, lifestyle, sex and socio-economic status. But identifying the factors that cause and modulate the ageing process often requires experimental interventions and modelling that can only be performed in model systems. Anne Brunet discusses the different model organisms that are used for the study of a...
Building a research group in China (when you have not mastered the language) means you face the same problems as elsewhere, with an extra bit of confusion. Running a research group in China with limited knowledge of Chinese is an interesting life experience, Luis Pedro Coelho tells us.
Starting a research group in a developing country can be economically, intellectually and personally challenging, but funding and other opportunities may be broader than they may seem from afar. Selene Fernandez-Valverde recounts her challenges in starting a research group in Mexico.
Mentorship is an important component of academic success. Here, I share my personal experience as a mentee and a mentor from the perspective of a junior principal investigator. Vaishnavi Ananthanarayanan, who is a junior PI at the Indian Institute of Science in Bangalore, India, shares her personal experience as a mentee and a mentor.
Premalignant skin stem cells become dependent on extracellular serine for proliferation, and this metabolic reprogramming inhibits tumour-suppressing cell differentiation.
A non-catalytic function of PRC1 is required for chromatin interactions that can facilitate developmental gene activation.
#1Hans Clevers (KNAW: Royal Netherlands Academy of Arts and Sciences)H-Index: 173
The coronavirus disease-19 (COVID-19) pandemic underscores the threat posed by newly emerging viruses. Understanding the biology of novel viruses rests in large part on in vitro models that allow viral replication. Human and animal organoids are now proving their value as an experimental virology platform. Hans Clevers discusses the value of organoids as an experimental platform for understanding the biology of novel viruses.
RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most frequent and conserved type of RNA modification. The addition of tails and their composition reflect RNA maturation stages and have important roles in determining the fate of the modified RNAs. Apart from canonical poly(A) polymerases, which add poly(A) tails to mRNAs in a transcription-coupled manner, a family of terminal nucleotidyltransferases (TENTs), including terminal uridylyltransferases (TUTs), mo...
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Stem cell
Computational biology
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