Cautions over the current epidemic of primary aldosteronism

Such percentages, ranging from 2·7% to 32%, are all based on the finding of raised plasma aldosterone to plasma renin activity ratios (ARR). The previous lower estimates and the more recent higher ones were largely derived from selected populations, so the frequency of primary aldosteronism in the overall hypertensive population remains uncertain. F R Buhler and colleagues first used the ARR in 1973 4 to identify people with low renin...