Original paper
Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ
Abstract
Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Our experiments show that Polq-null murine cells are selectively hypersensitive to DNA strand breaking agents, and that damage resistance requires the DNA polymerase activity of POLQ. Using a DNA break...
Paper Details
Title
Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ
Published Date
Oct 2, 2014
Journal
Volume
10
Issue
10
Pages
e1004654 - e1004654
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Notes
History