Original paper
The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration
Abstract
Cells often migrate in vivo in an extracellular matrix that is intrinsically three-dimensional (3D) and the role of actin filament architecture in 3D cell migration is less well understood. Here we show that, while recently identified linkers of nucleoskeleton to cytoskeleton (LINC) complexes play a minimal role in conventional 2D migration, they play a critical role in regulating the organization of a subset of actin filament bundles - the...
Paper Details
Title
The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration
Published Date
Jul 3, 2012
Journal
Volume
2
Issue
1
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Notes
History