Review paper
LacZ β‐galactosidase: Structure and function of an enzyme of historical and molecular biological importance
Abstract
This review provides an overview of the structure, function, and catalytic mechanism of lacZ β-galactosidase. The protein played a central role in Jacob and Monod's development of the operon model for the regulation of gene expression. Determination of the crystal structure made it possible to understand why deletion of certain residues toward the amino-terminus not only caused the full enzyme tetramer to dissociate into dimers but also...
Paper Details
Title
LacZ β‐galactosidase: Structure and function of an enzyme of historical and molecular biological importance
Published Date
Nov 13, 2012
Journal
Volume
21
Issue
12
Pages
1792 - 1807
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Notes
History