Free Drug Metabolic Clearance in Elderly People
Abstract
The question of whether metabolic drug clearance is decreased in elderly people has been the subject of considerable debate and is very important because clearance is a determinant of dosing. Drug clearance has been shown to be consistently impaired for flow-limited (high-clearance) drugs, but there have been conflicting results for capacity-limited (low-clearance) drugs. A limitation of the studies of capacity-limited drugs is that most have...
Paper Details
Title
Free Drug Metabolic Clearance in Elderly People
Published Date
Jan 1, 2008
Journal
Volume
47
Issue
5
Pages
297 - 321
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Notes
History