Original paper
Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high‐fat diet fed mice
Abstract
Background & Aims Mice fed high‐fat diet ( HFD ) demonstrate obesity‐related systemic insulin resistance ( IR ). Aim of this study is to clarify the role of interleukin ( IL )‐6 in IR in vivo focusing on skeletal muscle, adipose tissue and liver. Methods Plasma markers of IR and hepatic IL ‐6 signalling were examined in eight‐week HFD feeding C57/ BL 6 mice. Furthermore, IR ‐related molecules in skeletal muscles, adipose tissues and livers...
Paper Details
Title
Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high‐fat diet fed mice
Published Date
Aug 12, 2014
Journal
Volume
35
Issue
2
Pages
550 - 561
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Notes
History