Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high‐fat diet fed mice

Background & Aims Mice fed high‐fat diet ( HFD ) demonstrate obesity‐related systemic insulin resistance ( IR ). Aim of this study is to clarify the role of interleukin ( IL )‐6 in IR in vivo focusing on skeletal muscle, adipose tissue and liver. Methods Plasma markers of IR and hepatic IL ‐6 signalling were examined in eight‐week HFD feeding C57/ BL 6 mice. Furthermore, IR ‐related molecules in skeletal muscles, adipose tissues and livers...