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Liver International
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#1Ningfang Lian (Fujian Medical University)H-Index: 3
#2Su Lin (Fujian Medical University)H-Index: 4
Last. Han-Sheng Xie (Fujian Medical University)H-Index: 1
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Abstract As coronavirus disease 2019 (COVID-19) is a new, emerging infectious disease, guidance or consensus on liver injury are lacking2. The definition of COVID-19 associated liver injury in our manuscript was as alanine transaminase (ALT), aspartate aminotransferase (AST) or bilirubin above the upper limit of normal (ULN), which were 50 U/L, 40 U/L, and 26 ?mol/l respectively. The abnormal test results of ALT, AST and total bilirubin at baseline data were defined as liver injury in our manusc...
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#1Xiaoyan Cai (Southern Medical University)
#2Sulin Zheng (Southern Medical University)
Last. Yuli Huang (Southern Medical University)H-Index: 13
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In our recently published study, we reported that nonalcoholic fatty liver disease (NAFLD) is associated with increased risk of incident atrial fibrillation (AF). In minimally adjusted models without adjustment for cardiometabolic risk factors, NAFLD was associated with a 65% increased risk of AF. After adjustment for multiple cardiometabolic risk factors, the association between NAFLD and risk of AF was significant attenuated but still higher than that in non-NAFLD (RR 1.19, 95% CI 1.04-1.31).
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#1Sami Qadri (UH: University of Helsinki)H-Index: 1
#2Susanna Lallukka-Brück (UH: University of Helsinki)H-Index: 1
Last. Julia Perttilä (Minerva Foundation Institute for Medical Research)H-Index: 8
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BACKGROUND & AIMS: The I148M variant in PNPLA3 is the major genetic risk factor for non-alcoholic fatty liver disease (NAFLD). The liver is enriched with polyunsaturated triglycerides (PUFA-TGs) in PNPLA3-I148M carriers. Gene expression data indicate that PNPLA3 is liver-specific in humans, but whether it functions in adipose tissue (AT) is unknown. We investigated whether PNPLA3-I148M modifies AT metabolism in human NAFLD. METHODS: Profiling of the AT lipidome and fasting serum non-esterified f...
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#1Armand Abergel (CNRS: Centre national de la recherche scientifique)H-Index: 29
#2Tarik Asselah (Paris Diderot University)H-Index: 54
Last. Isabelle Fouchard-Hubert (University of Angers)H-Index: 18
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BACKGROUND: Genotype 1b is the most common HCV genotype worldwide, accounting for the largest proportion of infections in Europe, Russia, Latin America and Asia. Reducing treatment duration can improve adherence, reduce drug exposure and cost. Accordingly, we evaluated the efficacy of eight weeks fixed dose combination of grazoprevir-elbasvir in treatment-naive patients, with non-severe fibrosis. METHODS: HCV mono-infected and treatment naive patients with non-severe fibrosis (Fibroscan(R)<9.5kP...
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#1Jakob Paur (Medical University of Vienna)H-Index: 4
#2Max Valler (Medical University of Vienna)
Last. Andja Gvozdenovich (Medical University of Vienna)
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BACKGROUND&AIMS: Recently, over-expression of the fibroblast growth factor receptor 3 (FGFR3) splice variants FGFR3-IIIb and FGFR3-IIIc was found in ~50% of hepatocellular carcinoma (HCC). Here we aim to identify FGFR3-IIIb/IIIc ligands, which drive the progression of HCC. METHODS: FACS, MTT-assay and/or growth curves served to identify the FGFR3-IIIb/IIIc ligand being most effective to induce growth of hepatoma/hepatocarcinoma cell lines, established from human HCC. The most potent FGF was char...
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#1Sebastian K. Eder (Medical University of Vienna)H-Index: 3
#2A. FeldmanH-Index: 4
Last. Felix Stickel (UZH: University of Zurich)H-Index: 41
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BACKGROUND & AIMS: Approximately one third of patients with non-alcoholic fatty liver disease (NAFLD) show signs of mild to moderate iron overload. The impact of histological iron deposition on the clinical course of patients with NAFLD has not been established. METHODS & RESULTS: For this retrospective study, 299 consecutive patients with biopsy-proven NAFLD and a mean follow-up of 8.4 (+/-4.1; range: 0.3-18.0) years were allocated to one of four groups according to presence of hepatic iron in ...
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#1Alvaro Santos-Laso (UPV/EHU: University of the Basque Country)H-Index: 6
#2Laura Izquierdo-Sánchez (UPV/EHU: University of the Basque Country)H-Index: 1
Last. Maite G. Fernandez-Barrena (University of Navarra)H-Index: 13
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BACKGROUND & AIMS: Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple biliary cysts. Recently, novel PLD-causative genes, encoding for endoplasmic reticulum (ER)-resident proteins involved in protein biogenesis and transport, were identified. We hypothesized that aberrant proteostasis contributes to PLD pathogenesis, representing a potential therapeutic target. METHODS: ER stress was analysed at transcriptional (qPCR), proteomic (mass spec...
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#1Bernard Scheiner (Medical University of Vienna)
#2Patrick G. Northup (UVA: University of Virginia)H-Index: 23
Last. Mattias Mandorfer (Medical University of Vienna)H-Index: 19
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We thank Bitto and coworkers[1] for the interest in our study in which we tested the hypothesis whether ABO blood type would be a risk factor for portal vein thrombosis (PVT) in patients with advanced chronic liver disease (ACLD)[2]. In line with our findings, Bitto and coworkers provide data demonstrating that von Willebrand factor levels significantly differ between patients with O and non-O blood types in early stage ACLD, but not when they have more advanced disease[1]. These data thus confi...
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#2Praneet WanderH-Index: 2
Last. Sanjaya K. SatapathyH-Index: 14
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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious viral disease that predominantly causes respiratory symptoms. Elevated liver enzymes have been reported during the course of disease and appear to be common. We present a 56-yearold woman with a history of decompensated alcoholic cirrhosis who presented with abdominal pain, fever and diarrhea and was found to have acute on chronic liver failure secondary to SARS-CoV-2 infection. The patient was treated ...
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#1Zheng Ye (Sichuan University)
#2Bin Song (Sichuan University)
As coronavirus disease 2019 (COVID-19) is a new, emerging infectious disease, guidance or consensus on liver injury are lacking(2) . The definition of COVID-19 associated liver injury in our manuscript was as alanine transaminase (ALT), aspartate aminotransferase (AST) or bilirubin above the upper limit of normal (ULN), which were 50 U/L, 40 U/L, and 26 mumol/l respectively. The abnormal test results of ALT, AST and total bilirubin at baseline data were defined as liver injury in our manuscript.
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