Sibutramine Produces Dose‐Related Weight Loss

Sibutramine is a weight control drug that inhibits the reuptake of both serotonin and norepinephrine. In animals, it reduces food intake and increases thermogenesis and preliminary data in human beings showed weight loss. This paper reports a 24-week dose-ranging study to determine the effect of sibutramine on body weight of patients with obesity.Seven clinical centers screened 1463 patients with obesity and randomized 1047 to 24 weeks of...