Anticarcinogenic effects of (−)-epigallocatechin gallate

Background. Our research objective is to develop nontoxic cancer chemopreventive agents and to apply these agents in treating humans. We are identifying agents that inhibit the process of tumor promotion in two-stage carcinogenesis experiments on mouse skin. Methods. We review (a) the inhibitory effect of penta-O-galloyl-β-d-glucose (5GG) on tumor promotion by teleocidin, one of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters...