Match!

Variation in the dysbindin gene and normal cognitive function in three independent population samples

Published on Mar 1, 2009in Genes, Brain and Behavior3.16
· DOI :10.1111/j.1601-183X.2008.00462.x
Michelle Luciano41
Estimated H-index: 41
(Edin.: University of Edinburgh),
Fabio Miyajima14
Estimated H-index: 14
(University of Manchester)
+ 13 AuthorsAntony Payton33
Estimated H-index: 33
(University of Manchester)
Cite
Abstract
The association between DTNBP1 genotype and cognitive abilities was investigated in three population samples (1054 Scottish, 1806 Australian and 745 English) of varying age. There was evidence in each of the cohorts for association (P < 0.05) to single nucleotide polymorphisms (SNPs) and haplotypes previously shown to relate to cognition. By comparison with previous findings, these associations included measures of memory, and there was at best equivocal evidence of association with general cognitive ability. Of the SNPs typed in all three cohorts, rs2619528 and rs1011313 showed significant association with measures of executive function in two cohorts, rs1018381 showed significant association with verbal ability in one cohort and rs2619522 showed significance/marginal significance with tests of memory, speed and executive function in two cohorts. For all these SNPs, the direction and magnitude of the allelic effects were consistent between cohorts and with previous findings. In the English cohort, a previously untested SNP (rs742105) located in a distinct haplotype block upstream of the other SNPs showed the strongest significance (P < 0.01) for measures of memory but weaker significance for general cognitive ability. Our results therefore support involvement of the dysbindin gene in cognitive function, but further work is needed to clarify the specific functional variants involved and the cognitive abilities with which they are associated.
  • References (37)
  • Citations (42)
Cite
References37
Newest
#1Gary Donohoe (Trinity College, Dublin)H-Index: 42
#2Derek W. Morris (Trinity College, Dublin)H-Index: 53
Last.Aiden Corvin (Trinity College, Dublin)H-Index: 62
view all 10 authors...
#1Ian J. Deary (Edin.: University of Edinburgh)H-Index: 121
#2Alan J. Gow (Edin.: University of Edinburgh)H-Index: 39
Last.David J. Porteous (Edin.: University of Edinburgh)H-Index: 82
view all 10 authors...
#1Shaun Purcell (MIT: Massachusetts Institute of Technology)H-Index: 95
#2Benjamin M. Neale (MIT: Massachusetts Institute of Technology)H-Index: 76
Last.M. J. Daly (MIT: Massachusetts Institute of Technology)H-Index: 177
view all 10 authors...
#1Gary Donohoe (Trinity College, Dublin)H-Index: 42
#2Derek W. Morris (Trinity College, Dublin)H-Index: 53
Last.Aiden Corvin (Trinity College, Dublin)H-Index: 62
view all 10 authors...
#1Katherine E. Burdick (Albert Einstein College of Medicine)H-Index: 43
#2Terry E. Goldberg (North Shore-LIJ Health System)H-Index: 10
Last.Anil K. Malhotra (Albert Einstein College of Medicine)H-Index: 57
view all 7 authors...
Cited By42
Newest
#1Charlotte Sleurs (Katholieke Universiteit Leuven)H-Index: 3
#2Aline Madoe (Katholieke Universiteit Leuven)
Last.Anne Uyttebroeck (Katholieke Universiteit Leuven)H-Index: 25
view all 7 authors...
#1Frank Lee (UCLA: University of California, Los Angeles)H-Index: 2
#2Huei-Bin Wang (UCLA: University of California, Los Angeles)H-Index: 4
Last.Christopher S. Colwell (UCLA: University of California, Los Angeles)H-Index: 48
view all 10 authors...
#1Grace Kang Ning Tan (UTAR: Universiti Tunku Abdul Rahman)H-Index: 1
#2Shiau Foon Tee (UTAR: Universiti Tunku Abdul Rahman)H-Index: 5
Last.Pek Yee Tang (UTAR: Universiti Tunku Abdul Rahman)H-Index: 5
view all 3 authors...
#1Sern-Yih Cheah (QUT: Queensland University of Technology)H-Index: 4
#2Bruce R. Lawford (QUT: Queensland University of Technology)H-Index: 25
Last.Joanne Voisey (QUT: Queensland University of Technology)H-Index: 18
view all 5 authors...
View next paperGenetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.