ERK1/2 Regulates Epidermal Chemokine Expression and Skin Inflammation
Abstract
Resident cell populations of the skin contribute to the inflammatory response by producing an array of chemokines, which attract leukocytes from the circulation. TNF-alpha is a major inducer of proinflammatory mediators in keratinocytes. We have recently observed that epidermal growth factor receptor (EGFR) signaling affects TNF-alpha-driven chemokine expression in epidermal keratinocytes, and its functional impairment increases the levels of...
Paper Details
Title
ERK1/2 Regulates Epidermal Chemokine Expression and Skin Inflammation
Published Date
Apr 15, 2005
Journal
Volume
174
Issue
8
Pages
5047 - 5056
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Notes
History