Early Response of Mouse Joint Tissue to Noninvasive Knee Injury Suggests Treatment Targets

Objective Joint trauma can lead to a spectrum of acute lesions, including cartilage degradation, ligament or meniscus tears, and synovitis, all potentially associated with osteoarthritis (OA). This study was undertaken to generate and validate a murine model of knee joint trauma following noninvasive controlled injurious compression in vivo. Methods The right knees of 8‐week‐old mice were placed in a hyperflexed position and subjected to...