Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus

Adipose tissue (AT) content of the thigh is generally not considered to be associated with insulin resistance (IR), but it is unclear whether the distribution of AT in the thigh is a determinant of IR.We investigated whether subcompartments of AT within the thigh are determinants of IR.Midthigh AT, muscle composition, and insulin sensitivity were compared in 11 obese patients with type 2 diabetes mellitus (DM); 40 obese, glucose-tolerant (GT)...