Exercise tolerance in obese vs. lean adolescents: a systematic review and meta‐analysis

Published on Nov 1, 2014in Obesity Reviews8.192
· DOI :10.1111/obr.12202
Dominique Hansen23
Estimated H-index: 23
(University of Hasselt),
Nastasia Marinus2
Estimated H-index: 2
(University of Hasselt)
+ 5 AuthorsTim Takken44
Estimated H-index: 44
(UU: Utrecht University)
Summary To prescribe feasible and medically safe exercise interventions for obese adolescents, it remains to be determined whether exercise tolerance is altered and whether anomalous cardiopulmonary responses during maximal exercise testing are present. Studies that examined cardiopulmonary responses to maximal exercise testing in obese adolescents were searched: cardiopulmonary exercise tests with respiratory gas exchange measurements of peak oxygen uptake (VO2peak) were performed and comparisons between obese and lean adolescents were made. Study quality was assessed using a standardized item list. By meta-analyses VO2peak, peak cycling power output (Wpeak) and peak heart rate (HRpeak) were compared between groups. Nine articles were selected (333 obese vs. 145 lean adolescents). VO2peak (L min −1 ), HRpeak and Wpeak were not different between groups (P ≥ 0.10), while a trend was found for a reduced VO2peak (mL min −1 kg −1 lean tissue mass) (P = 0.07) in obese vs. lean adolescents. It remained uncertain whether anomalous cardiopulmonary responses occur during maximal exercise testing in obese adolescents. In conclusion, a trend was found for lowered VO2peak (mL min −1 kg −1 lean tissue mass) in obese vs. lean adolescents. Whether cardiopulmonary anomalies during maximal exercise testing would occur in obese adolescents remains uncertain. Studies are therefore warranted to examine the cardiopulmonary response during maximal exercise testing in obese adolescents.
  • References (28)
  • Citations (11)
📖 Papers frequently viewed together
1 Citations
4 Citations
9 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Dominique Hansen (University of Hasselt)H-Index: 23
#2Romain Meeusen (Vrije Universiteit Brussel)H-Index: 52
Last. Paul Dendale (University of Hasselt)H-Index: 31
view all 4 authors...
In subjects with obesity, the implementation of long-term exercise intervention increases lean tissue mass and lowers adipose tissue mass. However, data indicate a blunted lipolytic response, and/or skeletal muscle protein synthesis, when subjects with obesity are exposed to acute endurance or resistance exercise, respectively. Therefore, subjects with obesity seem to display a suboptimal physiological response to acute exercise stimuli. It might be hypothesized that hormonal disturbances contri...
26 CitationsSource
#1Monique Mendelson (French Institute of Health and Medical Research)H-Index: 3
#2Anne-Sophie Michallet (French Institute of Health and Medical Research)H-Index: 1
Last. Patrice Flore (French Institute of Health and Medical Research)H-Index: 16
view all 7 authors...
Abstract The aim of this study was to examine ventilatory responses to training in obese adolescents. We assessed body composition, pulmonary function and ventilatory responses (among which expiratory flow limitation and operational lung volumes) during progressive cycling exercise in 16 obese adolescents (OB) before and after 12 weeks of exercise training and in 16 normal-weight volunteers. As expected, obese adolescents’ resting expiratory reserve volume was lower and inversely correlated with...
11 CitationsSource
#1Santiago Lorenzo (UTSW: University of Texas Southwestern Medical Center)H-Index: 10
#2Tony G. BabbH-Index: 18
Background The quantification and interpretation of cardiorespiratory fitness (CRF) in obesity is important for adequately assessing cardiovascular conditioning, underlying comorbidities, and properly evaluating disease risk. We retrospectively compared peak oxygen uptake ( o 2 peak) (ie, CRF) in absolute terms, and relative terms (% predicted) using three currently suggested prediction equations (Equations R, W, and G). Methods There were 19 nonobese and 66 obese participants. Subjects underwen...
31 CitationsSource
#2Arnt Erik TjønnaH-Index: 20
Last. Ulrik WisløffH-Index: 69
view all 5 authors...
Objectives To measure cardiac function before and after 3 months of aerobic interval training in obese adolescents and to compare the findings with those in lean counterparts. Design Exercise intervention study. Cardiac function was assessed by echocardiography and maximal oxygen uptake by ergospirometry. Setting The obese adolescents were referred from general practice to the St Olav University Hospital, Trondheim, Norway, and the control group was recruited from 2 schools. Participants Ten obe...
59 CitationsSource
#1Hassane Zouhal (University of Rennes)H-Index: 21
#2Georges Jabbour (University of Rennes)H-Index: 7
Last. Christophe Jacob (University of Balamand)H-Index: 16
view all 7 authors...
The aim of this study was to investigate plasma catecholamine [adrenaline (A) and noradrenaline (NA)] concentrations at rest and in response to maximal exercise in three different groups of adolescent girls. According to their body mass index, 34 adolescent girls aged 15–16 years were divided into three groups: a normal weight group (NO) (n = 11), an overweight group (OW) (n = 11) and an obese group (OB) (n = 12). Plasma A and NA concentrations were measured at rest during fasting conditions (A ...
7 CitationsSource
#1Jennifer L. BakerH-Index: 29
Last. Ram WeissH-Index: 34
view all 5 authors...
The prevalence of obesity among children and adolescents is on the rise. The majority of overweight or obese children are treated by primary health care providers including paediatricians, family practitioners, dieticians, nurses, and school health services - and not by specialists. The majority of obese children have no underlying medical disorder causing their obesity yet a significant proportion might suffer from obesity-related co-morbidities. This text is aimed at providing simple and pract...
55 CitationsSource
#1Gert Jan Van Der Heijden (BCM: Baylor College of Medicine)H-Index: 3
#2Zhiyue J. WangH-Index: 32
Last. Agneta L. Sunehag (BCM: Baylor College of Medicine)H-Index: 23
view all 7 authors...
The rise in obesity-related morbidity in children and adolescents requires urgent prevention and treatment strategies. Currently, only limited data are available on the effects of exercise programs on insulin resistance, and visceral, hepatic, and intramyocellular fat accumulation. We hypothesized that a 12-week controlled aerobic exercise program without weight loss reduces visceral, hepatic, and intramyocellular fat content and decreases insulin resistance in sedentary Hispanic adolescents. Tw...
152 CitationsSource
#1Kristen J. Nadeau (University of Colorado Denver)H-Index: 30
#2P. Zeitler (University of Colorado Denver)H-Index: 5
Last. Judith G. Regensteiner (University of Colorado Denver)H-Index: 58
view all 8 authors...
Context: The incidence of pediatric type 2 diabetes (T2D) is rising, with unclear effects on the cardiovascular system. Cardiopulmonary fitness, a marker of morbidity and mortality, is abnormal in adults with T2D, yet the mechanisms are incompletely understood. Objective: We hypothesized that cardiopulmonary fitness would be reduced in youth with T2D in association with insulin resistance (IR) and cardiovascular dysfunction. Design, Setting, and Participants: We conducted a cross-sectional study...
123 CitationsSource
#1Hala Youssef (University of Rennes)H-Index: 8
#2Carole Groussard (University of Rennes)H-Index: 14
Last. Arlette Gratas-Delamarche (University of Rennes)H-Index: 22
view all 11 authors...
Exercise-induced oxidative stress in overweight adolescent girls: roles of basal insulin resistance and inflammation and oxygen overconsumption
18 CitationsSource
Abstract Background and aims Heart rate (HR) response to exercise has not been fully described in the obese. We wanted to study the differences between obese and non-obese patients in HR behavior during an exercise stress test and to determine whether these differences influence exercise capacity. Methods and results We studied 554 patients (318 females) who underwent a treadmill exercise test. All subjects were in sinus rhythm. Patients with ischemic heart disease, with reduced ejection fractio...
22 CitationsSource
Cited By11
#1Sheng-Hui TuanH-Index: 2
Last. Ko-Long LinH-Index: 2
view all 8 authors...
Objective Overweight and obesity in preschoolers might develop into childhood and even adulthood obesity. Overweight and obesity have been shown to be negatively related with cardiorespiratory fitness (CRF) in children and adults but few studies did among preschoolers. We aimed to evaluate whether excess body adipose is negatively associated with CRF in both the submaximal and maximal effort of preschool children in exercise testing and to examine if there is difference to achieve maximal effort...
#1P. Bokov (French Institute of Health and Medical Research)
#2Christophe Delclaux (French Institute of Health and Medical Research)H-Index: 37
Resume L’impact respiratoire de l’obesite est clinique (dyspnee de repos et/ou d’effort) et fonctionnel (explorations fonctionnelles respiratoires au repos et a l’exercice). La prevalence de la dyspnee est importante chez les obeses, presente chez environ 50 % des patients au repos et environ 75 % a l’effort chez l’adulte (score mMRC > 0). Les anomalies fonctionnelles respiratoires chez l’adulte sont caracterisees par une diminution principalement de la capacite residuelle fonctionnelle (CRF) et...
#1Aliva De (CUMC: Columbia University Medical Center)H-Index: 1
#2Deepa Rastogi (Albert Einstein College of Medicine)H-Index: 14
ABSTRACTIntroduction: Obesity affects about 40% of US adults and 18% of children. Its impact on the pulmonary system is best described for asthma.Areas covered: We reviewed the literature on PubMed...
#1Wouter M. A. Franssen (University of Hasselt)H-Index: 1
#2Marjolein Beyens (University of Hasselt)H-Index: 1
Last. Dominique Hansen (University of Hasselt)H-Index: 23
view all 9 authors...
To gain greater insights in the etiology and clinical consequences of altered cardiac function in obese adolescents. Therefore, we aimed to examine cardiac structure and function in obese adolescents, and to examine associations between altered cardiac function/structure and cardiometabolic disease risk factors or cardiopulmonary exercise capacity. In 29 obese (BMI 31.6 ± 4.2 kg/m², age 13.4 ± 1.1 years) and 29 lean (BMI 19.5 ± 2.4 kg/m², age 14.0 ± 1.5 years) adolescents, fasted blood samples w...
3 CitationsSource
#1Yanjun Xu (MPG: Max Planck Society)H-Index: 4
#2Annika F. Borcherding (MPG: Max Planck Society)
Last. Ronald P. Kühnlein (University of Graz)H-Index: 23
view all 6 authors...
Obesity is a progressive, chronic disease, which can be caused by long-term miscommunication between organs. It remains challenging to understand how chronic dysfunction in a particular tissue remotely impairs other organs to eventually imbalance organismal energy homeostasis. Here we introduce RNAi Pulse Induction (RiPI) mediated by short hairpin RNA (shRiPI) or double-stranded RNA (dsRiPI) to generate chronic, organ-specific gene knockdown in the adult Drosophila fat tissue. We show that organ...
#1Takashi Abe (University of Mississippi)H-Index: 45
#2Jeremy P. Loenneke (University of Mississippi)H-Index: 33
Last. Robert S. Thiebaud (Texas Wesleyan University)H-Index: 24
view all 3 authors...
Fat-free body mass (FFM) is a surrogate for skeletal muscle mass and is often used for the normalization of several physiological variables (e.g., oxygen uptake). However, FFM includes non-skeletal muscle components such as the fat-free component of adipose tissue fat cells. As the amount of adipose tissue mass increases, the FFM will also increase and be included in the measurement of FFM. Therefore, FFM may not be an appropriate indicator of muscle mass when targeting individuals with a large ...
2 CitationsSource
#1Hailu K. Alemayehu (University of Udine)H-Index: 1
#2Desy Salvadego (University of Udine)H-Index: 10
Last. Bruno Grassi (University of Udine)H-Index: 37
view all 8 authors...
2 CitationsSource
#1David ThivelH-Index: 8
#2G. O‘ MalleyH-Index: 12
Last. Julien AucouturierH-Index: 16
view all 3 authors...
While obesity mainly results from an imbalance between energy intake and expenditure, physical activity has to be part of prevention and treatment strategies, especially among children and adolescents. Increasing physical activity level mainly depends on the ability to perform exercise, necessitating an objective and accurate evaluation of physical fitness, both aerobic and anaerobic. While this chapter describes how overall fitness is altered by pediatric obesity, it also provides clinicians an...
#1Franz Joachim MeyerH-Index: 10
#2Mathias M. BorstH-Index: 21
Last. H. WorthH-Index: 18
view all 16 authors...
Dieses Dokument der DGP ersetzt die Empfehlungen von 1998 und 2013. Anhand der aktuellen Datenlage und einer Konsensuskonferenz wurden Empfehlungen zu Indikationen, zur Auswahl und Durchfuhrung der geeigneten Belastungsuntersuchungen sowie zu den technischen und personellen Voraussetzungen formuliert. Detaillierte Angaben werden zur Blutgasanalyse unter Belastung, zu Gehtests und Rechtsherzkatheter unter Belastung sowie zur Spiroergometrie und Stressechokardiografie gemacht. Der korrekte Einsatz...
3 CitationsSource
#1Dominique Hansen (University of Hasselt)H-Index: 23
#2Wendy HensH-Index: 5
Last. Dirk VissersH-Index: 13
view all 7 authors...
Worldwide, an obesity epidemic among children and adolescents is apparent. In the care of obesity in children and adolescents, exercise therapy is considered a cornerstone. Official position statements describe and endorse the need and effect of exercise therapy and increased physical activity in children and adolescents with obesity. Physical therapists working in private and home care settings (first-line treatment) can play a key role in maximizing participation rates in exercise and physical...
5 CitationsSource