Exposure to occupational antigens might predispose to IgG4‐related disease

IgG4-associated cholangitis (IAC) and autoimmune pancreatitis are the predominant manifestations of IgG4-related diseases (IgG4-RD); their pathogenesis is enigmatic.1, 2 Serum IgG4 concentrations are generally elevated in IgG4-RD but the biological implications thereof have not been explained.3 IgG4, traditionally regarded as a regulatory antibody, has been consistently reported to be upregulated in chronic immune stimulation, as illustrated by...