Original paper
The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth
Abstract
Early B cell development is orchestrated by the combined activities of the transcriptional regulators E2A, EBF1, Foxo1 and Ikaros. However, how the genome-wide binding patterns of these regulators are modulated during B lineage development remains to be determined. Here we found that in lymphoid progenitor cells, the chromatin remodeler Brg1 specified the B cell fate. In committed pro-B cells, Brg1 regulated contraction of the locus encoding the...
Paper Details
Title
The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth
Published Date
May 18, 2015
Journal
Volume
16
Issue
7
Pages
775 - 784
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Notes
History