Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation

A deficit in glucose uptake and a deposition of amyloid β-peptide (Aβ) each occur in vulnerable brain regions in Alzheimer’s disease (AD). It is not known whether mechanistic links exist between Aβ deposition and impaired glucose transport. We now report that Aβ impairs glucose transport in cultured rat hippocampal and cortical neurons by a mechanism involving membrane lipid peroxidation. Aβ impaired 3 H-deoxy-glucose transport in a...