Original paper
Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic β-cells (HIT)
Abstract
Stimulation of insulin release by glucose requires increased metabolism of glucose and a rise in cytosolic free Ca2+ in the pancreatic beta-cell. It is accompanied by increases in respiratory rate, pyridine and flavin nucleotide reduction state, intracellular pH and the ATP/ADP ratio. To test alternative proposals of the regulatory relationships among free Ca2+, mitochondrial metabolism and cellular energy state, we determined the temporal...
Paper Details
Title
Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic β-cells (HIT)
Published Date
May 1, 1996
Journal
Volume
315
Issue
3
Pages
1015 - 1019
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Notes
History