Regulation of Exocytosis from Single Visualized GABAergic Boutons in Hippocampal Slices

Regulation of GABA release is crucial for normal brain functioning, and GABA A -mediated IPSCs are strongly influenced by repetitive stimulation and neuromodulation. However, GABA exocytosis has not been examined directly in organized tissue. Important issues remain outside the realm of electrophysiological techniques or are complicated by postsynaptic factors. For example, it is not known whether all presynaptic modulators affect release from...