Origins of Programmable Nucleases for Genome Engineering
Abstract
Genome engineering with programmable nucleases depends on cellular responses to a targeted double-strand break (DSB). The first truly targetable reagents were the zinc finger nucleases (ZFNs) showing that arbitrary DNA sequences could be addressed for cleavage by protein engineering, ushering in the breakthrough in genome manipulation. ZFNs resulted from basic research on zinc finger proteins and the FokI restriction enzyme (which revealed a...
Paper Details
Title
Origins of Programmable Nucleases for Genome Engineering
Published Date
Feb 1, 2016
Journal
Volume
428
Issue
5
Pages
963 - 989
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