Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Abstract
Crohn's disease and ulcerative colitis, the two main types of chronic inflammatory bowel disease, are multifactorial conditions of unknown aetiology. A susceptibility locus for Crohn's disease has been mapped to chromosome 16. Here we have used a positional-cloning strategy, based on linkage analysis followed by linkage disequilibrium mapping, to identify three independent associations for Crohn's disease: a frameshift variant and two missense...
Paper Details
Title
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Published Date
May 1, 2001
Journal
Volume
411
Issue
6837
Pages
599 - 603
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