Abstract 13311: Cardiac SIRT1 Deficiency Sensitizes Myocardium to Ischemia and Reperfusion Injury

Introduction: A “longevity” gene, sirtuin 1 (SIRT1) is a conserved NAD + -dependent protein deacetylase that regulates life span extension. We have reported that SIRT1 is down-regulated in the aged heart which shows larger infarct size and deteriorative heart function during ischemia and reperfusion (I/R) compared with that of young heart. Hypothesis: Cardiac specific SIRT1 deficiency could increase the sensitivity of heart to ischemic insults...