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Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing
Published on Jun 1, 1998in American Journal of Pathology 4.07
Nicholas N. Nissen2
Estimated H-index: 2
(Loyola University Chicago),
Peter J. Polverini14
Estimated H-index: 14
+ 3 AuthorsLuisa A. DiPietro41
Estimated H-index: 41
Abstract
Angiogenesis is an essential component of normal wound repair, yet the primary mediators of wound angiogenesis have not been well described. The current study characterizes the contribution of vascular endothelial cell growth factor (VEGF) to the angiogenic environment of human surgical wounds. Surgical wound fluid samples (n = 70) were collected daily for up to 7 postoperative days (POD) from 14 patients undergoing mastectomy or neck dissection. VEGF levels in surgical wound fluid were lowest on POD 0, approximating values of serum, but increased steadily through POD 7. An opposite pattern was noted for basic fibroblast growth factor-2. Fibroblast growth factor-2, which has been previously described as a wound angiogenic factor, exhibited highest levels at POD 0, declining to near serum levels by POD 3. Surgical wound fluid form all time points stimulated marked endothelial cell chemotaxis and induced a brisk neovascular response in the rat corneal micropocket angiogenesis assay. Antibody neutralization of VEGF did not affect the in vitro chemotactic or the in vivo angiogenic activity early wound samples (POD 0). In contrast, VEGF neutralization significantly attenuated both chemotactic activity (mean decrease 76 +/- 13%, P < 0.01) and angiogenic activity (5 of 5 samples affected) of later wound samples (POD 3 and 6). The results suggest a model of wound angiogenesis in which an initial angiogenic stimulus is supplied by fibroblast growth factor-2, followed by a subsequent and more prolonged angiogenic stimulus mediated by VEGF.
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Cited By621
Published on Jan 1, 2008
V. Do Diana1
Estimated H-index: 1
(Johns Hopkins University School of Medicine),
Julia A. Haller51
Estimated H-index: 51
(Johns Hopkins University School of Medicine)
+ 4 AuthorsAntonia M. Joussen37
Estimated H-index: 37
(University of Düsseldorf)
1 Citations Source Cite
Peng-Fei Cao1
Estimated H-index: 1
,
Yingbin Xu10
Estimated H-index: 10
+ 2 AuthorsXusheng Liu9
Estimated H-index: 9
Hypertrophic scars are fibroproliferative disorders of excessive wound healing after skin injury. Vascular endothelial growth factor (VEGF)-induced angiogenesis plays a major role in fibrogenesis and hypertrophic scar formation. Over recent years, there has been a major interest in homeobox gene regulation of VEGF-VEGFR mediated angiogenesis in dermal tissue. In the current study, we investigated the role of homeobox genes in the epidermis, for their role in angiogenesis, with a focus on epiderm...
5 Citations
Published on Jan 1, 2015
Steven Sampson2
Estimated H-index: 2
,
Angie Botto-van Bemden1
Estimated H-index: 1
,
Danielle Aufiero4
Estimated H-index: 4
Source Cite
Published on Jan 1, 1999
Angiogenesis, the growth of new capillaries from preexisting blood vessels, is essential for tumour growth and the development of metastases. Vascular endothelial growth factor is the most potent angiogenic factor identified to date Tamoxifen has been shown to inhibit angiogenesis m a manner independent of the oestrogen receptor. The expression of VEGF in breast cancer, possible regulators, and evidence for a VEGF related inhibition of angiogenesis by tamoxifen was examined. BT474 and MDA-MB-231...
Published on Jan 1, 2013
Giuseppe Curigliano37
Estimated H-index: 37
(European Institute of Oncology),
Janaina Brollo5
Estimated H-index: 5
(European Institute of Oncology),
Maximiliano Cassilha Kneubil5
Estimated H-index: 5
(European Institute of Oncology)
Normal wound repair generates an angiogenic response to deliver nutrients and inflammatory cells to injured tissue. The angiogenic response facilitates the removal of debris and is central to the development of a granulation tissue framework for wound closure. The mediators of wound angiogenesis include soluble factors such as vascular endothelial growth factor, tumor necrosis factor, transforming growth factor β, basic fibroblast growth factor, and platelet-derived growth factor, which have bee...
Source Cite
Published on Jan 1, 2010
Jerrold S. Petrofsky28
Estimated H-index: 28
,
Gurinder Bains11
Estimated H-index: 11
8 Citations Source Cite
Published on Feb 14, 2011
Placenta growth factor (PlGF), a member of the vascular endothelial growth factor (VEGF) protein family, is a critical regulator of vascular growth during processes of tissue remodelling including tissue repair and carcinogenesis. As reported for VEGF-A, the PlGF gene gives raise to different protein isoforms by mRNA splicing, which differ primarily in the presence or absence of a carboxyl-terminal domain, rich in basic amino acids (so called heparin-binding domain). The most abundantly expresse...
Hmc Shantha Kumara2
Estimated H-index: 2
,
Elizabeth A. Myers4
Estimated H-index: 4
+ 7 AuthorsRichard L. Whelan35
Estimated H-index: 35
Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection
2 Citations Source Cite
Published on Jan 1, 2004in Cancer treatment and research
Vinay K. Puduvalli27
Estimated H-index: 27
(University of Texas MD Anderson Cancer Center)
Multidisciplinary treatment strategies for patients with malignant brain tumors have resulted in only small gains in terms of prognosis in spite of the use of aggressive therapy. There is a growing realization that a paradigm shift is needed in the conceptual approaches to glioma therapy. Such approaches will rely on identification and modification of key cellular targets that define the biological behavior of these tumors. Among the targets for such treatment approaches, tumor angiogenesis has ...
29 Citations Source Cite
Published on Jan 1, 2003in Methods in molecular medicine
Mark W. Lingen43
Estimated H-index: 43
(University of Chicago)
10 Citations Source Cite
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