Calcium modulation of exocytosis-linked plasma membrane potential oscillations in INS-1 832/13 cells
Abstract
In the presence of high glucose or pyruvate, INS-1 832/13 insulinoma cells undergo stochastic oscillations in plasma membrane potential (Δψp) leading to associated fluctuations in cytosolic free Ca(2+) concentration ([Ca(2+)]c). Oscillations are not driven by upstream metabolic fluctuations, but rather by autonomous ionic mechanisms, the details of which are unclear. We have investigated the nature of the oscillator, with simultaneous...
Paper Details
Title
Calcium modulation of exocytosis-linked plasma membrane potential oscillations in INS-1 832/13 cells
Published Date
Sep 21, 2015
Journal
Volume
471
Issue
1
Pages
111 - 122
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