Neurotransmitter and Neuromodulator Genes Associated With a History of Depressive Symptoms in Individuals With Alcohol Dependence

Depressive symptoms are common among individuals with alcohol use disorders and impact treatment outcome. Substantial overlap exists among the neurobiological systems proposed in the pathophysiology of depressive and alcohol use disorders; however, specific genetic effects contributing to risk for depressive comorbidity remain poorly understood.This study examines the association of depressive symptom scores for lifetime depression (the sum of...