Review paper
Vedolizumab for induction and maintenance of remission in ulcerative colitis
Abstract
Background Cellular adhesion molecules play an important role in the pathogenesis of ulcerative colitis, making selective blockade of these molecules a promising therapeutic strategy. Vedolizumab, a recombinant humanized IgG1 monoclonal antibody, inhibits adhesion and migration of leukocytes into the gastrointestinal tract by binding the alpha4beta7 integrin. Animal studies have suggested that vedolizumab may be a useful therapy for ulcerative...
Paper Details
Title
Vedolizumab for induction and maintenance of remission in ulcerative colitis
Published Date
Aug 8, 2014
Journal
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Notes
History