Adenosine activates A2 receptors to inhibit neutrophil adhesion and injury to isolated cardiac myocytes.
Abstract
Inhibition of neutrophil-myocyte adhesion and adhesion-dependent myocyte injury by adenosine was evaluated using isolated TNF-alpha-activated canine cells. Adenosine inhibited adhesion of activated neutrophils to cardiac myocytes with an IC50 of 11 +/- 4 nM. Inhibition of neutrophil adhesion (92 +/-3% by 100 nM adenosine) led to inhibition of myocyte injury (by 90 +/- 6%, as assessed by dye exclusion). Inhibition of cell adhesion by adenosine...
Paper Details
Title
Adenosine activates A2 receptors to inhibit neutrophil adhesion and injury to isolated cardiac myocytes.
Published Date
Sep 1, 1995
Journal
Volume
155
Issue
5
Pages
2579 - 2586
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