Impairment of mitochondrial function by minocycline

There is an ongoing debate on the presence of beneficial effects of minocycline (MC), a tetracycline‐like antibiotic, on the preservation of mitochondrial functions under conditions promoting mitochondria‐mediated apoptosis. Here, we present a multiparameter study on the effects of MC on isolated rat liver mitochondria (RLM) suspended either in a KCl‐based or in a sucrose‐based medium. We found that the incubation medium used strongly affects...