Original paper
Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening
Abstract
Cholesterol plays an important role in living cells. However, a very high level of cholesterol may lead to atherosclerosis. HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase is the key enzyme in the cholesterol biosynthesis pathway, and the statin-like drugs are inhibitors of human HMG-CoA reductase (hHMGR). The present study aimed to virtually screen for potential hHMGR inhibitors from natural product to discover hypolipidemic drug...
Paper Details
Title
Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening
Published Date
Jun 1, 2015
Pages
3313 - 3313
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Notes
History