Fetal Deficiency of Lin28 Programs Life-Long Aberrations in Growth and Glucose Metabolism
Abstract
LIN28A/B are RNA binding proteins implicated by genetic association studies in human growth and glucose metabolism. Mice with ectopic over-expression of Lin28a have shown related phenotypes. Here, we describe the first comprehensive analysis of the physiologic consequences of Lin28a and Lin28b deficiency in knockout (KO) mice. Lin28a/b-deficiency led to dwarfism starting at different ages, and compound gene deletions showed a cumulative dosage...
Paper Details
Title
Fetal Deficiency of Lin28 Programs Life-Long Aberrations in Growth and Glucose Metabolism
Published Date
Aug 1, 2013
Journal
Volume
31
Issue
8
Pages
1563 - 1573
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