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The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers: A Systematic Review

Published on May 1, 2005in Journal of the American College of Cardiology18.639
· DOI :10.1016/j.jacc.2004.12.077
Christos Kasapis1
Estimated H-index: 1
(UConn: University of Connecticut),
Paul D. Thompson87
Estimated H-index: 87
(Hartford Hospital)
Abstract
Physical activity is associated with a reduced incidence of coronary disease, but the mechanisms mediating this effect are not defined. There has been considerable recent interest in inflammation in the pathogenesis of cardiovascular disease. Some of the beneficial role of physical activity may result from its effects on the inflammatory process. We searched PubMed for articles published between 1975 through May 2004 using the terms exercise, physical activity, or physical fitness combined with C-reactive protein, inflammation, inflammatory markers, or cytokines. The review revealed 19 articles on the acute inflammatory response to exercise, 18 on cross-sectional comparisons of subjects by activity levels, and 5 examining prospectively the effects of exercise training on the inflammatory process. Exercise produces a short-term, inflammatory response, whereas both cross-sectional comparisons and longitudinal exercise training studies demonstrate a long-term “anti-inflammatory” effect. This anti-inflammatory response may contribute to the beneficial effects of habitual physical activity.
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References63
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#1D. Verdaet (Free University of Brussels)H-Index: 1
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#2Muhammad Sheikh-Ahmad (Rappaport Faculty of Medicine)H-Index: 3
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Abstract Introduction: Physical fitness has a protective effect with regard to the risk of developing coronary disease or diabetes. C-reactive protein (CRP) levels are directly related to increased risk of coronary disease and diabetes. However, data on the association between physical fitness and CRP are sparse. Methods: Physical fitness was assessed in a population-based cross-sectional study ( n = 892; age 50 ± 9 years) using the Bruce treadmill protocol. CRP was measured using a high-sensiti...
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Elevated high-sensitivity c-reactive protein (hs-CRP) is associated with increased risk of future first and recurrent coronary events and has been associated with both high body mass index (BMI) and low physical activity in cross sectional studies. Purpose: To longitudinally examine the effects of BMI and both current and previous-year physical activity on hs-CRP in healthy men and women (N = 109). Methods: BMI and hs-CRP were measured five times (baseline and quarterly) over I yr. Current physi...
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KING, D. E., P. CAREK, A. G. MAINOUS III, and W. S. PEARSON. Inflammatory Markers and Exercise: Differences Related to Exercise Type. Med. Sci. Sports Exerc., Vol. 35, No. 4, pp. 575–581, 2003. To examine the relationship between elevated inflammatory markers (CRP, fibrinogen, and white blood cell levels) and various forms of exercise for the adult U.S. population while controlling for factors that might influence the relationship. An analysis of the adults age 17 and over who participated in th...
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