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Anti-inflammatory activity of Tribulus terrestris in RAW264.7 Cells (54.2)

Published on May 1, 2012in Journal of Immunology 4.72
Joa-Sub Oh8
Estimated H-index: 8
(DU: Dankook University),
Seung Ho Baik1
Estimated H-index: 1
+ 2 AuthorsSeong Su Hong20
Estimated H-index: 20
Inflammation is involved in various diseases, including chronic inflammatory disease and arthritis. The inflammation induced by the production of cyclooxygenease (COX)-2 and inducible nitric oxide synthase (iNOS), which are important mediators of inflammation. In this study, we investigated the ethanol extract of Tribulus terrestris (ETT) inhibited expression of COX-2 and iNOS in lipopolysaccharide(LPS)- stimulated RAW264.7 cells. We observed that ETT significantly decreased release of NO production in a dose-dependent manner in LPS-stimulated RAW264.7 cells. ETT also suppressed expression of proinflammtory cytokines, such as TNF-α and IL-4 in macrophage cell line. Our findings suggest that ETT inhibits expression of mediators related to inflammation and expression of inflammatory cytokines, which has a beneficial effect on various inflammatory diseases.
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Cited By4
Published on May 1, 2019in Neurochemical Research 2.78
R. Ranjithkumar , Qasim Alhadidi5
Estimated H-index: 5
(UT: University of Toledo)
+ 1 AuthorsMuthiah Ramanathan
The present study has been aimed to explore the different secondary messengers of the inflammatory pathway NF-κB, kinases (JNK, P38MAPK, GSK3β/βcatenin), apoptosis pathway (Caspase-3 and AIF), and neuronal survival pathway (BDNF) in order to understand the neuroprotective mechanism of aqueous extract of Tribulus terrestris (AQTT). In primary cortical neurons, the ischemic condition was induced through oxygen–glucose deprivation (OGD). Anti-inflammatory activity of AQTT was evaluated in formalin ...
Published on Dec 1, 2016in Journal of Ethnopharmacology 3.41
Oratai Neamsuvan4
Estimated H-index: 4
(PSU: Prince of Songkla University),
Pattaraporn Bunmee1
Estimated H-index: 1
(PSU: Prince of Songkla University)
Abstract Ethnopharmacological relevance Skin diseases are common health problems which affecting to all ages. In Thailand, the number of patients diagnosed with skin diseases is increasing every year. Nowadays, The Ministry of Public Health is supporting and promoting herbs for treating various disorders, including disorders of the skin to reduce the problem of antibiotic resistance and adverse drug reactions. This study aimed to: (1) enumerate the herbal weeds for treating skin disorders; (2) s...
Published on Jul 13, 2016
In Ayurveda texts, Charak Samhita deals with 50 different group of 10 herbs each with specific action and uses. It also deals with different basic formulations like Swarasa (juice), Kalka (paste), Kashaya (decoction) etc. Dashamoola is one of such 50 group of herbs as the name contains root of ten different plants i.e. Bilva, Gambhari, Shyonaka, Patala, Agnimantha, Prishniparni, Salparni, Kantakari, Vrihati & Gokshura . Of these, first five’s are known as Brihad panchamoola and the remaining as ...
Published on Jan 1, 2015in Tropical Journal of Pharmaceutical Research 0.44
Amina El-Shaibany2
Estimated H-index: 2
Molham AL-Habori1
Estimated H-index: 1
+ 1 AuthorsShaza M. Al Massarani1
Estimated H-index: 1
Purpose : To investigate the anti-hyperglycaemic activity of methanol extract of Tribulus terrestris L. Zygophyllaceae in glucose-loaded normal rabbits. Methods: The animals were randomly assigned to 4 groups (n = 5) and treated with a single oral dose. Group 1 served as normal control group and received distilled water; group 2 served as hyperglycaemic control; group 3 was treated with glibenclamide (5 mg/kg, aqueous suspension) and served as reference standard; group 4 received methanol extrac...
Divya Menon K1
Estimated H-index: 1
Sheema Dharmapal1
Estimated H-index: 1
+ 1 AuthorsBabu T D1
Estimated H-index: 1
Tribulus terrestris L. (Family: Zygophyllaceae) has been used extensively for various human ailments by different traditional systems of medicine including Ayurveda. Recently, the anti-proliferative effect of this plant against breast cancer cells was reported. In the present study, the cytotoxic and antitumour effects of the methanolic extract of T. terrestris fruits were analysed. On in vitro cytotoxicity analysis, the extract showed 50% inhibitory concentration (IC50) at 380 and 420 µg/ml, fo...
Published on Jan 1, 2014in Pharmacognosy Reviews
Saurabh Chhatre1
Estimated H-index: 1
Tanuja Nesari1
Estimated H-index: 1
+ 2 AuthorsSadhana Sathaye12
Estimated H-index: 12
(Government of Maharashtra)
Tribulus terrestris (family Zygophyllaceae), commonly known as Gokshur or Gokharu or puncture vine, has been used for a long time in both the Indian and Chinese systems of medicine for treatment of various kinds of diseases. Its various parts contain a variety of chemical constituents which are medicinally important, such as flavonoids, flavonol glycosides, steroidal saponins, and alkaloids. It has diuretic, aphrodisiac, antiurolithic, immunomodulatory, antidiabetic, absorption enhancing, hypoli...